The Giant Centipede was one of the monsters that was forced to fight in the Monster Arena. It was shown battling the Shrewster from the episode Twister. This is strange, because the Shrewster was supposed to be living on Monster Island, indicating that it either escaped or was stolen from the facility. After its battle with the Shrewster, the Giant Centipede is returned to its containment cell. It was not released again to do battle against Zilla Junior, and thus, its ultimate fate is unknown.
Being an enlarged version of a normal centipede, the Giant Centipede possessed no special abilities. It could have instead used its large claw-like appendages and possible body toxins to defend itself from opponents.